【摘 要】
：
In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-AIDs drug(compounds 5 and 7) was synthesized. Compou
【机 构】
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College of Life Science,School of Pharmacy,Affiliated Hospital
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In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-AIDs drug(compounds 5 and 7) was synthesized. Compound 5 was synthesized by linking the delavirdine deri- vative to pidotimod, compound 7 was synthesized via linking the delavirdine derivative to resveratrol with terephthalic acid as the conjugated compound by two different routes. The structures were confirmed by means of 1H NMR, 13C NMR, IR, MS and elemental analysis. The results for HIV-1 reverse transcriptase assay, quantitative titration of HIV-1 by using MAGI assay and pharmacokinetics assay show that a novel kind of anti-AIDs drug has been synthesized.
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