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实验动物为雌性小鼠。甲组16鼠灌服150mg/kg沙蚕毒素系新农药杀虫单,其中中毒死亡的占93.8％(15只)。乙组16鼠在灌服同剂量前24小时予先给50％四氯化碳0.1ml,其死亡率为56.3％(9只),两组差异显著(P<0.05)。丙组16鼠在灌服同剂量杀虫单后二分钟给50％四氯化碳0.1ml,13只死亡 (占81.3％),和甲组比较,其差异不显著 (P>0.05)。剖鼠三组鼠的肝脏,观察和比较肝外形和色泽,并镜检肝组织切片:予先给四氯化碳存活小鼠的肝损害程度较同组的死亡小鼠为重,甲组和丙组小鼠的肝组织病变并不明显。实验结果提示:四氯化碳可保护杀虫单急性中毒小鼠而减少死亡,它和肝组织的损害程度相关。本文还联系同系杀虫剂巴丹的构效关系,探讨杀虫单在体内生物转化的可能途径和四氯化碳抑制肝微粒体混合功能氧化酶的作用。
Experimental animals were female mice. A group of 16 mice were given 150 mg/kg nematicitin-based new pesticides, of which 93.8% (15) died of poisoning. Rats in group B were given 5 ml of carbon tetrachloride 0.1 ml 24 hours before the same dose, and the mortality rate was 56.3% (nine). There was a significant difference between the two groups (P<0.05). 16 rats in group C were given 5 ml of carbon tetrachloride 0.1 ml two minutes after the same dose of insecticide-batch was administered, and 13 died (81.3%). Compared with group A, the difference was not significant (P>0.05). The livers of three groups of mice were dissected to observe and compare the shape and color of the liver, and the liver tissue sections were examined by microscopy. The pre-existing carbon tetrachloride-survival mice were heavier than the same group of dead mice. Liver lesions in group C mice were not obvious. The experimental results suggest that carbon tetrachloride can protect the acute poisoning mice and reduce death, which is related to the extent of liver damage. This article also contacted the structure-activity relationship of the insecticide Bataan to investigate the possible pathways of biotransformation of the insecticide in vivo and the role of carbon tetrachloride in inhibiting the mixed function of liver microsomes.