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目的探讨甲胎蛋白(alpha fetal protein,AFP)、血清总蛋白(total protein,TP)、白蛋白(albumin,ALB)以及超氧化物歧化酶(superoxide dismutase,SOD)在肝病患者中的变化及其临床意义。方法对200例符合纳入标准的肝病患者及50例正常对照组样本同时进行AFP、TP、ALB以及SOD的检测,对检测结果采用t检验和c2检验进行统计分析,比较4个指标在肝病患者与正常对照组间、肝病患者与肝癌患者间的差异以及其对肝病的检测敏感度。结果正常对照组与肝癌组及肝硬化组的AFP、TP、ALB、SOD检测结果相比,差异具有统计学意义(P<0.05);而正常对照组与肝炎组的AFP、ALB、SOD检测结果比对显示差异有统计学意义(P<0.05),TP检测结果显示差异无统计学意义(P>0.05);对比分析肝癌组与肝硬化组检测结果显示,AFP、SOD差异有统计学意义(P<0.05),TP、ALB检测结果显示差异无统计学意义(P>0.05);对比分析肝癌组与肝炎组检测结果显示,AFP、ALB、SOD差异有统计学意义(P<0.05),TP检测结果显示差异无统计学意义(P>0.05);c2检验分析样本异常检出率可见3组中AFP、ALB、SOD异常检出率差异有统计学意义(P<0.05);而TP阳性检出率3组间差异无统计学意义(P>0.05)。结论肝病患者血清AFP、TP、ALB、SOD与健康者存在显著性差异,且随着病情的加重其异常检出率也随之增加,可作为指示肝病患者病情的检测指标。
Objective To investigate the changes of alpha-fetoprotein (AFP), total protein (TP), albumin (ALB) and superoxide dismutase (SOD) Clinical significance. Methods AFP, TP, ALB and SOD were detected simultaneously in 200 cases of liver disease patients and 50 cases of normal control group. The test results were analyzed by t test and c2 test. The results of four indicators in patients with liver disease and The difference between the normal control group, liver disease patients and liver cancer patients and their sensitivity to detection of liver disease. Results The differences of AFP, TP, ALB and SOD between the normal control group and the liver cancer group and the cirrhosis group were statistically significant (P <0.05), while the results of AFP, ALB and SOD in the normal control group and the hepatitis group The results of TP showed no significant difference (P> 0.05). Comparing the results of liver cancer with cirrhosis showed that the difference of AFP and SOD was statistically significant (P <0.05) (P <0.05). The results of TP and ALB showed no significant difference (P> 0.05). The results of liver cancer group and hepatitis group showed that the difference of AFP, ALB and SOD was statistically significant (P <0.05) The results of c2 test showed that there was no significant difference between the two groups (P> 0.05). The positive rate of abnormal detection of AFP, ALB and SOD in the three groups was statistically significant (P <0.05) There was no significant difference between the three groups (P> 0.05). Conclusion Serum AFP, TP, ALB, SOD in patients with liver disease have significant difference with healthy people, and the abnormal detection rate increases with the severity of the disease, which can be used as a indicator of the disease in patients with liver disease.