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目的研究艾司西酞普兰联合胰岛素治疗糖尿病合并焦虑抑郁症状患者的临床效果。方法选取我院从2014年5月至2015年6月收治的糖尿病伴焦虑抑郁症状的患者80例,采用随机数字表法将80例患者分为观察组(40例)和对照组(40例);对照组采取常规胰岛素治疗,观察组在对照组的基础上联用艾司西酞普兰。观察对比两组患者的临床有效率、HAMD评分、HAMA评分以及餐后2h血糖与糖化血红蛋白。结果观察组的临床有效率87.50%显著高于对照组67.50%(P<0.05);观察组的HAMA评分与HAMD评分明显低于对照组(P<0.05);观察组的餐后2h血糖与糖化血红蛋白均显著低于对照组(P<0.05)。两组不良反应率没有统计学差异(P>0.05)。结论艾司西酞普兰联合胰岛素治疗糖尿病焦虑抑郁症状的患者具有明显的临床效果,减轻患者的负性情绪,使患者的血糖水平得到有效的控制。
Objective To study the clinical effect of escitalopram combined with insulin in the treatment of diabetic patients with anxiety and depression symptoms. Methods Eighty patients with diabetic mellitus and anxiety and depression who were treated in our hospital from May 2014 to June 2015 were enrolled. Eighty patients were divided into observation group (40 cases) and control group (40 cases) by random number table. ; The control group to take conventional insulin treatment, the observation group in the control group based on escitalopram. The clinical efficacy, HAMD score, HAMA score, and 2h postprandial blood glucose and HbA1c were compared between the two groups. Results The clinical effective rate in observation group was significantly higher than that in control group (87.50%, 67.50%, P <0.05). HAMA score and HAMD score in observation group were significantly lower than those in control group (P <0.05) Hemoglobin was significantly lower than the control group (P <0.05). Adverse reactions between the two groups showed no significant difference (P> 0.05). Conclusion Escitalopram in combination with insulin treatment of diabetic patients with anxiety and depression symptoms have obvious clinical effects, reduce the patient’s negative emotions, so that patients with blood glucose levels are effectively controlled.