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目的探讨肝硬化患者合并肺部感染的危险因素。方法以2005年1月-2009年12月518例肝硬化患者为研究对象,采用病例对照的研究方法,回顾性分析感染发生情况和危险因素。结果 144例肝硬化合并肺部感染,感染率27.8%,病死率13.19%。显著高于无感染患者的病死率6.69%(P<0.01),临床表现早期不典型,主要危险因素经Logistic多因素分析显示是,child-pugh分级为C级、年龄≥60岁、病毒性肝炎、上消化道出血史、脾亢/脾切除、合并其他系统感染,合并基础疾病是相对独立危险因素。结论重视肝硬化患者的病情分级,年龄病因,并发症、合并基础疾病能更好地预防控制肝硬化合并肺部感染。
Objective To investigate the risk factors of pulmonary infection in patients with cirrhosis. Methods A total of 518 patients with cirrhosis from January 2005 to December 2009 were enrolled in this study. Case-control study methods were used to analyze the incidence of infection and risk factors. Results 144 cases of cirrhosis with pulmonary infection, the infection rate was 27.8%, the case fatality rate was 13.19%. The mortality was 6.69% (P <0.01) in patients without infection. The clinical manifestations were not typical in early stage. The main risk factors were Logistic multivariate analysis, child-pugh grade C, age 60 years, viral hepatitis , History of upper gastrointestinal bleeding, hypersplenism / splenectomy, combined with other systemic infections, and underlying diseases are relatively independent risk factors. Conclusion The emphasis on the classification of patients with cirrhosis, age etiology, complications, combined with basic diseases can better prevent and control cirrhosis with pulmonary infection.