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目的观察前列地尔联合硫辛酸治疗糖尿病周围神经病变的临床疗效及不良反应。方法将88例糖尿病周围神经病变患者随机分为观察组和对照组各44例,所有患者均积极控制血糖治疗,对照组给予硫辛酸调节神经治疗;观察组给予前列地尔联合硫辛酸治疗。两组患者疗程均为21 d,观察两组患者临床症状改善情况及药物不良反应。结果 21 d后疗效:观察组总有效率为90.9%,对照组总有效率为79.5%。两组患者总有效率比较差异有统计学意义(P<0.05)。两组患者不良反应均轻微,未见严重不良反应。结论前列地尔联合硫辛酸治疗糖尿病周围神经病变临床疗效好,不良反应无明显增加,值得临床推广应用。
Objective To observe the clinical efficacy and adverse reactions of alprostadil combined with lipoic acid in the treatment of diabetic peripheral neuropathy. Methods 88 patients with diabetic peripheral neuropathy were randomly divided into the observation group and the control group, 44 cases, all patients were actively controlled blood glucose treatment, the control group was given lipoic acid-mediated neurological treatment; observation group was given alprostadil combined with lipoic acid therapy. Two groups of patients were treated for 21 days, observed two groups of patients with clinical symptoms and adverse drug reactions. Results 21 d after the curative effect: the total effective rate was 90.9% in the observation group, the control group, the total effective rate was 79.5%. The total effective rate of two groups was statistically significant difference (P <0.05). Adverse reactions in both groups were mild, no serious adverse reactions. Conclusion Alprostadil combined with lipoic acid in the treatment of diabetic peripheral neuropathy clinical efficacy, no significant increase in adverse reactions, it is worth promoting the clinical application.