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采用染色体Ｇ带的分析方法对３５例睾丸生殖细胞肿瘤进行了研究，初级细胞培养获得１０例异常核型。为观察、分析１２号染色体的畸变形式，将与１２号染色体畸变有关的核型及其临床资料进行比较、分析。结果表明，该染色体的畸变形式有：＋１２（７０％），ｉ（１２ｐ）（７０％）、１２ｑ＋（５０％）、１２ｑ－（２０％）。其中，非精原细胞瘤的＋１２、ｉ（１２ｐ）发生率明显高于精原细胞瘤（Ｐ＜０．０５，＜０．０１）。结论：由于ｉ（１２ｐ）在睾丸生殖细胞肿瘤具有较高的特异性，故可作为其标记染色体；＋１２和ｉ（１２ｐ）在非精原细胞瘤的高发生率，有助于理解精原细胞瘤向非精原细胞瘤转化的机制。
35 cases of testicular germ cell tumors were studied using the method of chromosome G band analysis, and 10 cases of abnormal karyotype were obtained in primary cell culture. To observe and analyze the aberrant forms of chromosome 12, karyotype associated with chromosome 12 aberration and its clinical data were compared and analyzed. The results showed that the chromosome aberrations were: +12 (70%), i (12p) (70%), 12q + (50%) and 12q- (20%). Among them, the incidence of non-seminoma + 12, i (12p) was significantly higher than that of seminoma (P <0.05, <0.01). CONCLUSIONS: Because i (12p) is highly specific in testicular germ cell tumors, it can be used as a marker chromosome. The high incidence of +12 and i (12p) in nonseminomatous neoplasms may help to understand the relationship between spermatogonia The mechanism of tumor transformation into non-seminoma.