目的 :研究小剂量雌二醇和孕酮对绝经后妇女骨质疏松的影响 ,以评估其疗效。方法 :将 6 8例绝经3年以上 ,年龄 (5 2 5 9)岁 ,平均 5 6岁 ,体重指数不超过 2 5 ,经GBD— 92 8单光子骨矿物质密度测定仪测量前臂尺、桡骨远端 1 / 3处的骨矿物质密度 (BMD)的水平 ,诊断为骨质疏松的妇女 ,分成两个组进行治疗。第一组 36例为对照组 ,每天仅用乐力 2 0 0 0mg ,第二组 32例为治疗组 ,每天除用乐力 2 0 0 0mg外 ,加用 1 7βE2 0 5mg和醋酸甲羟孕酮 (MPA) 0 5mg。在治疗前、后 ,所有受试者均经BMD、妇检、阴道B超、阴道细胞学和乳房红外线检查。结果 :所有受试者在治疗前BMD的水平 ( x±s,g/cm2 )为 0 4 6± 0 0 7;治疗 1年后 ,对照组 :0 4 9± 0 0 5 ,均值比治疗前升高 3% ;治疗组 :0 5 2± 0 0 6 ,均值比治疗前升高 6 % ;治疗组中 ,有 1 0例患者在治疗前有轻度乳腺小叶增生 ,9例有 <1cm2 子宫肌瘤 ,在给予 1 7βE2 、MPA和钙剂治疗的同时 ,给予中成药平消胶囊和舒肝散进行治疗。 1年后 ,乳腺小叶增生者有 6例好转 ,4例不变。子宫小肌瘤者 4例略有缩小 ,5例不变。其余所有对象治疗 1年后 ,各项检查均未见异常。结论 :本文结果表明 ,仅用钙剂治疗绝经后妇女骨质疏松的疗效较差 ,钙剂加小剂量 1 7βE2 和M OBJECTIVE: To study the effect of low-dose estradiol and progesterone on osteoporosis in postmenopausal women to assess their efficacy. Methods: Sixty-eight menopausal men with over 3 years old, aged (5259) years old, with an average of 56 years old and a body mass index of no more than 25 were measured. The forearm ulnar radius was measured by GBD-92 8 single photon bone mineral density meter The level of bone mineral density (BMD) at the distal end 1/3, diagnosed as osteoporosis, was divided into two groups for treatment. 36 cases of the first group as the control group, daily music only 2000 mg, the second group of 32 patients in the treatment group, every day in addition to 2 000 mg of music, plus 1 7βE2 0 5mg and medroxyprogesterone acetate Ketone (MPA) 0 5mg. Before and after treatment, all subjects underwent BMD, gynecological examination, vaginal ultrasonography, vaginal cytology and breast infrared. Results: The BMD level (x ± s, g / cm2) of all subjects before treatment was 0 46 ± 0 0 7; after 1 year of treatment, the control group was 0 49 ± 0 0 5, Increased by 3%; treatment group: 0 5 2 ± 0 0 6, the mean increased 6% than before treatment; treatment group, 10 patients with mild breast lobular hyperplasia before treatment, 9 cases with <1cm2 uterus Fibroids, given 1 7βE2, MPA and calcium treatment at the same time, given Pingyao Ping capsule and Shugan powder for treatment. After 1 year, 6 cases of breast lobular hyperplasia improved, 4 cases unchanged. 4 cases of uterine fibroids slightly reduced, 5 cases unchanged. All other subjects after 1 year of treatment, the examination showed no abnormalities. CONCLUSIONS: The results of this study indicate that the efficacy of calcium alone in the treatment of postmenopausal osteoporosis is poor. Calcium plus small doses of 17βE2 and M