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目的:探讨粪便乳铁蛋白作为溃疡性结肠炎活动性标志物的可能性。方法:选取溃疡性结肠炎患者42例,对照组炎症性肠病患者20例,采用酶联免疫吸附试验法测定粪便乳铁蛋白的含量,同时测定实验室指标白细胞计数、红细胞沉降率(ESR)、C反应蛋白(CPR)的水平。结果:1)溃疡性结肠炎组活动期粪便乳铁蛋白的含量显著高于缓解期和对照组,且活动期组轻、中、重度三级之间差异有统计学意义;粪便乳铁蛋白的含量随着内镜的分级程度的增高而增高,但与溃疡性结肠炎内镜分级之间相关性不明显r=0.4199(P=0.0517)。2)粪便乳铁蛋白对判断溃疡性结肠炎的活动性的特异性和敏感性显著高于外周血白细胞计数、C反应蛋白、红细胞沉降率。结论:粪便乳铁蛋白对溃疡性结肠炎活动性的判定价值显著高于白细胞计数、C反应蛋白、红细胞沉降率,但是否可以作为理想的替代肠镜的炎症性标志物还有待进一步的大样本研究。
Objective: To investigate the possibility of fecal lactoferrin as an active marker of ulcerative colitis. Methods: Forty-two patients with ulcerative colitis and 20 patients with inflammatory bowel disease were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) was used to determine the content of lactoferrin in the feces and to determine the leucocyte count, erythrocyte sedimentation rate (ESR) , C-reactive protein (CPR) levels. Results: 1) The content of lactoferrin in feces of patients with ulcerative colitis was significantly higher than that of remission and controls (P <0.05), and there was a statistically significant difference between the mild, moderate and severe levels in active patients. Fecal lactoferrin The content increased with the degree of endoscopy grading, but it was not significantly correlated with the endoscopic grade of ulcerative colitis (r = 0.4199, P = 0.0517). 2) The specificity and sensitivity of fecal lactoferrin to determine the activity of ulcerative colitis was significantly higher than that of peripheral blood leukocyte count, C-reactive protein and erythrocyte sedimentation rate. Conclusion: The diagnostic value of fecal lactoferrin for ulcerative colitis activity is significantly higher than that of white blood cell count, C-reactive protein and erythrocyte sedimentation rate, but whether it can be used as an ideal alternative inflammatory marker of enteroscopy still needs further large sample the study.