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神经干细胞(neural stem cell NSC)具有自我更新和多分化潜能这两个基本属性,目前已成为神经组织移植治疗中枢神经疾病和神经损伤修复的研究焦点,大量的动物实验为神经干细胞移植提供了理论依据,全能的干细胞既可以在体外无限制的增值分裂,保持未分化状态,又可在一定条件下向神经细胞分化,为神经干细胞移植提供了物质条件。 1 神经干细胞的概念,来源与特性 1.1 对 NSC 的精确定义尚存在某些争论,自1992 年 Reynolds 等从胚胎鼠脑的纹状体区首次分离出能在体外持续增殖且具有向神经元及星形胶质细胞
Neural stem cell (NSC) has the basic properties of self-renewal and multi-differentiation and has become the research focus of nerve tissue transplantation for the treatment of central nervous system diseases and nerve injury. A large number of animal experiments provide the theory for neural stem cell transplantation Basis, all-powerful stem cells both in vitro unlimited value-added division, remain undifferentiated state, but also under certain conditions differentiate into nerve cells for neural stem cell transplantation provides the material conditions. 1 CONCEPTS, SOURCES AND CHARACTERISTICS OF NERVOUS STEM CELL 1.1 Precise definition of NSC There is some controversy. Since 1992, Reynolds et al. First isolated from the striatum of the embryonic rat brain in vitro and continuously proliferated in vitro and showed neurons and stars Astrocytes