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用随机双盲双模拟法比较了国产丁二酸洛沙平与盐酸氯丙嗪治疗２０５例精神分裂症的研究结果。洛沙平组１０４例，氯丙嗪组１０１例，疗程８周。结果显示：两组疗效相似，有效率均为８９．１％，洛沙平组显效率６１．４％，氯丙嗪显效率４９．５％。洛沙平作用起效快且持久，对青春型的ＢＰＲＳ总分减分率与氯丙嗪组有显著的差异（Ｐ＜０．０５）。两组副作用基本相似。洛沙平的主要副反应有静坐不能、便秘、震颤、出汗，个别病例有心电图ＳＴＴ段的改变及癫痫大发作。
The results of 205 cases of schizophrenia treated with loxapine succinate and chlorpromazine hydrochloride were compared by double-blind double-dummy randomized trial. 104 cases in loxapine group and 101 cases in chlorpromazine group for 8 weeks. The results showed that: the two groups were similar efficacy, the effective rate was 89.1%, the effective rate of loxapine was 61.4%, chlorpromazine efficiency was 49.5%. Losapine has a rapid onset and long-lasting effects. There was a significant difference (P <0.05) between the BPRS total score reduction rate and the chlorpromazine group. Side effects of both groups were similar. The main side effects of loxapine are sedentary, constipation, tremors, sweating, individual cases of ST segment ECG changes and epilepsy seizures.