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运动作为一种辅助治疗手段,在癌症诊治过程中受到了广泛关注。本研究旨在观察运动对米托蒽醌载药纳米粒治疗早期乳腺癌疗效的影响。60只接种了BCAP-37乳腺癌细胞的Balb/c雌性小鼠被随机分成4组:(a)空白对照组;(b)无药运动组;(c)药物组;(d)运动+药物组。运动组小鼠每天以15 m/min的速度跑转笼30 min,每周跑6 d,持续4周。每周测试2次肿瘤体积以观察肿瘤的生长情况。通过血常规检验观察药物副作用。相比于空白对照组,在药物组和运动+药物组发现肿瘤体积的增长趋势明显减缓(P<0.05;P<0.01),运动+药物组最终的肿瘤体积与药物组相比有统计学差异(P<0.05)。药物组小鼠的HGB与运动+药物组相比出现显著差异(P<0.05)。运动可以增强载药纳米粒的治疗效果并且降低化疗的副作用。在癌症的治疗过程中,运动是一种有效的辅助治疗手段。
As a supplementary treatment method, exercise has received extensive attention in the process of cancer diagnosis and treatment. This study aimed to observe the effect of exercise on the efficacy of mitoxantrone-loaded nanoparticles in the treatment of early-stage breast cancer. 60 Balb/c female mice inoculated with BCAP-37 breast cancer cells were randomly divided into 4 groups: (a) blank control group; (b) drug-free exercise group; (c) drug group; (d) exercise+drug group. The mice in the exercise group ran for 30 minutes every day at a speed of 15 m/min for 6 days per week for 4 weeks. Tumor volume was measured twice weekly to observe tumor growth. The drug side effects were observed through routine blood tests. Compared with the blank control group, the growth trend of tumor volume was significantly slowed in the drug group and exercise+drug group (P<0.05; P<0.01). The final tumor volume in the exercise+drug group was statistically different from that of the drug group. (P<0.05). There was a significant difference in HGB between the drug group and the exercise+drug group (P<0.05). Exercise can enhance the therapeutic effect of drug-loaded nanoparticles and reduce the side effects of chemotherapy. In the treatment of cancer, exercise is an effective supplementary treatment.