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探讨低剂量格拉诺赛特（ｒｈＧ－ＣＳＦ）对淋巴瘤ＣＨＯＰＥ化疗后白细胞和中性粒细胞减少的防治作用。采用随机分组、自身交叉对比的方法。患者随机分为Ａ、Ｂ两组，Ａ组第一周期化疗后加ｒｈＧ－ＣＳＦ，第二周期单用化疗；Ｂ组第一周期单用化疗，第二周期化疗后加ｒｈＧ－ＣＳＦ。ｒｈＧ－ＣＳＦ在化疗药物末次给药后４８ｈ起，５０μｇ／日，皮下注射。结果表明，该剂量的ｒｈＧ－ＣＳＦ可以明显减轻化疗过程中的白细胞和中性粒细胞下降的程度，降低感染率，使化疗可以如期进行。低剂量的ｒｈＧ－ＣＳＦ疗效确切，副反应轻微，值得推广。
To investigate the preventive and therapeutic effects of low-dose grananoside (rhG-CSF) on leucocyte and neutropenia after chemotherapy with lymphoma CHOPE. Use random grouping and cross-contrast methods. The patients were randomly divided into two groups, A and B. Group A received rhG-CSF after the first cycle of chemotherapy, and the second cycle used chemotherapy alone; group B received chemotherapy only during the first cycle and rhG-CSF after the second cycle. rhG-CSF was injected subcutaneously at 48 hours after the last administration of the chemotherapeutic agent, 50 μg/day. The results show that this dose of rhG-CSF can significantly reduce the degree of leukocyte and neutrophil depletion during chemotherapy, reduce the infection rate, and enable chemotherapy to proceed as scheduled. Low-dose rhG-CSF has a definite curative effect with minor side effects and is worthy of promotion.