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目的:探讨肾移植对儿童终末期肾病(ESRD)的疗效、手术处理、免疫抑制剂应用方法。方法:总结我院1985年1月至2001年12月21例接受肾移植的患儿临床资料、植肾手术方法、免疫抑制剂应用和随访情况。结果:术后早期平均肾功能恢复时间为5.6天。1、3、5年/存活率分别为95.2%、86.7%/73.3%。72.7%/63.6%.最长存活12年。其中1例发生超急性排斥反应.5侧发生急性排斥反应.3例出现移植物功能延迟恢复,3例死亡。术后主要并发症有:高血压(47.6%)、糖尿病(19.4%)、感染(19.4%)、药物性肝损害(14.2%).结论:肾移植是治疗儿童ESRD最为理想的方法。儿童可以适应成人肾脏的移植。术后免疫抑制治疗建议联合应用强地松+霉酚酸酯+FK506。
Objective: To investigate the efficacy of renal transplantation in children with end-stage renal disease (ESRD), surgical treatment, immunosuppressive agents. Methods: From January 1985 to December 2001 in our hospital, 21 cases of children undergoing renal transplantation in clinical data, renal transplant surgery, immunosuppressive agents and follow-up. Results: The mean recovery time of early renal function after operation was 5.6 days. One, three, five years / survival rates were 95.2%, 86.7% / 73.3% respectively. 72.7% / 63.6%. The longest survival of 12 years. Among them, 1 case had hyperacute rejection, 5 cases had acute rejection, 3 cases showed delayed graft recovery and 3 died. The major postoperative complications were hypertension (47.6%), diabetes mellitus (19.4%), infection (19.4%) and drug-induced liver damage (14.2%) .Conclusion: Kidney transplantation is the most ideal treatment for children with ESRD. Children can adapt to adult kidney transplants. Postoperative immunosuppressive therapy recommended combination of prednisone + mycophenolate mofetil + FK506.