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3,4-O-异亚丙基莽草酸(ISA)是从木兰科植物八角茴香(Illicium verum Hook.Fil.)中提取的有效成分莽草酸的衍生物,具有抗炎、抗血栓和抗缺血性脑损伤等作用,关于其对于阿尔茨海默病的作用尚不清楚.本研究发现,ISA可显著改善SAMP-8快速老化小鼠(Mus musculus)的空间学习记忆能力,降低脑皮层IL-1,IL-6,TNF-?和Caspase-3水平,降低海马区p-Tau蛋白表达,升高海马区沉默信息调节因子2同源蛋白1(SIRT1)蛋白表达.本研究表明,ISA可通过抑制过度神经炎性反应、增加SIRT1表达,降低Tau蛋白磷酸化,改善阿尔茨海默病造成的认知功能损伤.
3,4-O-isopropylidene shikimic acid (ISA) is an active ingredient of shikimic acid extracted from the genus Illicium verum Hook.Fil., And has anti-inflammatory, anti-thrombotic and anti-ischemic effects Brain damage and so on, its role in Alzheimer’s disease is not clear.The study found that ISA can significantly improve SAMP-8 rapid aging mouse (Mus musculus) spatial learning and memory, reduce cerebral cortex IL 1, IL-6, TNF-|Á and Caspase-3 levels in hippocampus of rats, and decreased the expression of p-Tau protein in hippocampus, and increased the expression of SIRT1 protein in hippocampus. By inhibiting the excessive neuroinflammatory reaction, increasing SIRT1 expression, reducing phosphorylation of Tau protein and improving cognitive impairment caused by Alzheimer’s disease.