论文部分内容阅读
目的:观察氯沙坦联用胺碘酮在心房颤动(房颤)复律后维持窦性心律的作用及对左房大小的影响。方法:93例房颤患者,复律后随机分为2组:A组给予胺碘酮治疗;B组在服用胺碘酮的基础上加用氯沙坦。观察2组治疗前后左心房大小变化和房颤复发情况。结果:随访1年后B组的窦性心律的维持率明显高于A组,差异有统计学意义(P<0.05);B组治疗后较治疗前左房内径显著缩小(P<0.05),A组治疗前后无差异。结论:氯沙坦联用胺碘酮在房颤复律后维持窦性心律较单用胺碘酮更有效,并可逆转左房扩大。
AIM: To observe the effect of losartan and amiodarone on maintenance of sinus rhythm after cardioversion of atrial fibrillation (AF) and its effect on the size of left atrium. Methods: A total of 93 patients with atrial fibrillation were randomly divided into 2 groups: group A received amiodarone; group B received losartan on the basis of taking amiodarone. The changes of left atrium size and recurrence of atrial fibrillation before and after treatment were observed in two groups. Results: The maintenance rate of sinus rhythm in group B was significantly higher than that in group A at 1 year after follow-up (P <0.05). The diameter of left atrium in group B was significantly reduced (P <0.05) A group before and after treatment no difference. Conclusion: Losartan combined with amiodarone to maintain sinus rhythm after cardioversion is more effective than amiodarone alone, and can reverse the enlargement of left atrium.