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目的 :探讨米索前列醇和米非司酮对初孕妇宫颈扩张的最佳给药方式及剂量选择。方法 :通过 2 4 7例初孕妇人工流产 ,随机比较不同给药方式米非司酮和米索前列醇对宫颈的扩张作用、减少术中出血及减轻药物副反应等。结果 :各用药组对宫颈的扩张作用与对照组相比有显著差异 (P <0 .0 1) ;米索阴道放药组明显高于其他各组 (P <0 .0 1) ;阴道放置米索组术中副反应发生率明显低于其他各组 (P <0 .0 1) ;米索组出血量低于米非司酮组及对照组 ,给药途径与出血量多少无关 (P >0 .0 5 ) ;阴道给药组药物副反应发生率低于口服给药组 (P <0 .0 1)。结论 :阴道放置米索前列醇 4 0 0 μg不仅能扩张宫颈 ,而且能减轻药物副反应 ,值得人工流产前应用。
OBJECTIVE: To investigate the optimal dosage and dosage of misoprostol and mifepristone for cervical dilatation in early pregnant women. Methods: Through 247 abortions of first trimester pregnant women, we randomly compared the effects of different administrations of mifepristone and misoprostol on cervical dilatation, reducing intraoperative bleeding and alleviating side effects of drugs. Results: The dilatation effects of each drug group on cervix were significantly different from that of the control group (P <0.01); the misoprostol group was significantly higher than the other groups (P <0.01); vaginal Misoprostol group incidence of side effects was significantly lower than the other groups (P <0. 01); misoprostol group was lower than the mifepristone group and the control group, route of administration has nothing to do with the amount of bleeding (P > 0. 05). The incidence of adverse reactions in the vaginal administration group was lower than that in the oral administration group (P <0.01). Conclusion: Misdiagnosis with 400 μg of misoprostol can not only expand the cervix, but also reduce side effects of the drug, which is worth the prenatal application.