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目的研究急性一氧化碳中毒后迟发性脑病(DEACMP)的临床表现、脑电图、影像学特征及其治疗和预后。方法对2009-11-2010-02收治的39例DEACMP患者进行回顾分析。结果 DEACMP的临床表现多样,以痴呆、二便失禁、智能障碍为主。CT或MRI提示脑内白质的对称性类圆形低密度影。治疗强调高压氧,同时给予激素、神经细胞活化剂、血管扩张剂等联合治疗,预后良好。结论 DEACMP发病的程度与发病年龄、昏迷时间、接触CO时间、高压氧治疗、并发症、既往病史及合并症等因素相关。
Objective To study the clinical manifestation, EEG, radiological features, treatment and prognosis of de novo encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods 39 patients with DEACMP admitted from 2009-11-2010-02 were retrospectively analyzed. Results The clinical manifestations of DEACMP varied with dementia, fecal incontinence and mental retardation. CT or MRI brain white matter symmetry class round low density. Treatment emphasizes hyperbaric oxygen, while giving hormones, nerve cell activators, vasodilators and other joint treatment, the prognosis is good. Conclusion The incidence of DEACMP is related to age of onset, coma time, exposure to CO, hyperbaric oxygen therapy, complications, previous medical history and comorbidities.