8月龄肾性(2K,1C)高血压大鼠灌服钙拮抗剂硝苯吡啶10mg/kg/d,共30天,药物降压效果显著,与文献报道一致。同龄正常组(n=9),高血压组(n=6)和用药组(n=7)大鼠断头取出心脏,按常规匀浆离心制得心肌膜标本。用~3H-Prazcsin进行放射配基受体结合分析,数据经计算机软件Scatchard作图计算,结果如下;正常组Bmax=43.31±5.42fmol/mg蛋白,Kd=0.11±0.03nM。高血压组Bmax=54.46±6.16 Eight-month-old renal (2K, 1C) hypertensive rats were drenched with nifedipine 10 mg / kg / d for 30 days. The antihypertensive effect of the drug was remarkable and consistent with that reported in the literature. The normal rats of the same age (n = 9), the hypertensive group (n = 6) and the medication group (n = 7) were decapitated and the myocardium samples were obtained by centrifugation. Radioligand binding assay was performed with ~ 3H-Prazcsin. The data were calculated by computer software Scatchard. The results were as follows: Normal group Bmax = 43.31 ± 5.42fmol / mg protein, Kd = 0.11 ± 0.03nM. Hypertension group Bmax = 54.46 ± 6.16