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目的:观察苯那普利对糖尿病肾病高血压及蛋白尿的疗效。方法:在常规降糖治疗基础上,加用苯那普利10～20mg/d,不再加用其它降压药物,连用4周1疗程,治疗前和治疗后分别测量血压,24小时尿蛋白,血肌酐及血尿素氮。结果:治疗4周后收缩压、舒张压均明显降低(P<0.01),24小时尿蛋白定量明显减少(P<0.01),而且肌酐及尿素氮无明显变化(P>0.05)。结论:糖尿病肾病伴高血压的患者服用苯那普利有较好的疗效,而且短期内对肾功能影响不大。
Objective: To observe the effect of benazepril on hypertension and proteinuria in diabetic nephropathy. Methods: On the basis of routine hypoglycemic treatment, benazepril was added at 10-20mg / d, no further antihypertensive drugs were added, once every 4 weeks for 1 course of treatment. Blood pressure, 24-hour urine protein , Serum creatinine and blood urea nitrogen. Results: After 4 weeks of treatment, the systolic and diastolic blood pressure were significantly decreased (P <0.01), and the proteinuria in 24 hours was significantly decreased (P <0.01), but there was no significant change in creatinine and urea nitrogen (P> 0.05). Conclusion: Benazepril is effective in patients with diabetic nephropathy and hypertension and has little effect on renal function in short term.