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目的探讨以质子泵抑制剂奥美拉唑三联疗法根除幽门螺杆菌(Hp)的疗效。方法对157例经胃镜检查和病理诊断为慢性胃炎、胃溃疡的患者,随机分为治疗组和对照组。治疗组采用OAC方案,奥美拉唑20mg次/,阿莫西林胶囊1.0g次/,克拉霉素片0.5g次/,均2次/d口服,疗程7d。对照组使用OAM方案,奥美拉唑20mg次/,阿莫西林胶囊1.0g次/,甲硝唑片0.4g次/,均为2次/d口服,疗程7d。治疗1周后停药,4~8周后行14C尿-素呼气试验,阴性为治愈。结果治疗组治愈率为93.67%,对照组治愈率为85.90%,两组间治愈率差异无统计学意义(P>0.05)。结论OAC方案疗效较好,是当前根除幽门螺杆菌感染首选的一线方案。
Objective To investigate the efficacy of proton pump inhibitor omeprazole triple therapy in the eradication of Helicobacter pylori (Hp). Methods A total of 157 patients with gastroscopy and pathological diagnosis of chronic gastritis and gastric ulcer were randomly divided into treatment group and control group. OAC regimen, omeprazole 20 mg / time, amoxicillin capsule 1.0 g / time, clarithromycin 0.5 g / time were administrated twice a day for 7 days. OAM regimen was used in the control group, omeprazole 20mg times /, amoxicillin capsule 1.0g times /, metronidazole tablets 0.4g times /, were 2 times / d oral, treatment 7d. One week after the treatment, the patients were stopped and the 14C urine-to-breath test was performed after 4 to 8 weeks. The negative was cured. Results The cure rate was 93.67% in the treatment group and 85.90% in the control group. There was no significant difference in the cure rate between the two groups (P> 0.05). Conclusion The OAC regimen has good curative effect and is the first-line plan for the eradication of Helicobacter pylori infection.