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目的建立一种利用1个对照品,同步计算测定解热消炎胶囊多成分的定量分析方法。方法测定解热消炎胶囊的指纹图谱,以黄芩苷峰为基准峰,分别计算绿原酸及栀子苷与其的相对校正因子,外标法测定黄芩苷的含量,用校正因子计算绿原酸及栀子苷的含量;同时与外标法测定结果进行比较,以验证方法可行性和科学性。结果建立了解热消炎胶囊的含量控制方法,方法结果与外标法测定结果无显著性差异。结论一标多评法既能同时测定多种成分,又能节约对照品的使用,有望成为适合中药特点的多指标质量评价新模式。
OBJECTIVE To establish a quantitative analysis method for simultaneous determination of multi-component antipyretic and anti-inflammatory capsule using 1 reference substance. Methods Fingerprints of antipyretic and antiphlogistic capsule were determined. Based on the peak of baicalin, the relative correction factors of chlorogenic acid and geniposide were calculated. The content of baicalin was determined by external standard method. The chlorogenic acid and Geniposide content; at the same time with the external standard test results were compared to verify the feasibility and scientific method. Results The method of controlling the content of anti-inflammatory anti-inflammatory capsule was established. There was no significant difference between the method and the external standard method. Conclusion One standard multiple assessment method not only can measure many kinds of components at the same time, but also can save the use of reference substance. It is expected to be a new model of multi-index quality evaluation suitable for traditional Chinese medicine.