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目的:考察十一方药酒的急性毒性、皮肤刺激性和过敏性。方法:采用健康家兔进行急性毒性和皮肤刺激性试验,采用健康豚鼠进行皮肤过敏性试验。结果:家兔完整皮肤及破损皮肤单次用药(临床等效剂量的53,27,13倍),14 d内无中毒表现,呼吸、进食等活动正常,体重分别增长6.97%和6.67%;家兔完整皮肤和破损皮肤单次给药,连续7 d,均未见刺激性;十一方药酒对豚鼠皮肤无致敏性。结论:十一方药酒对家兔皮肤无急性毒性和刺激作用,对豚鼠皮肤无致敏作用。
OBJECTIVE: To investigate the acute toxicity, skin irritation and allergy of eleven prescription wine. Methods: Healthy rabbits were used for acute toxicity and skin irritation test, and healthy guinea pigs were used for skin allergy test. Results: The intact skin and damaged skin of rabbits received single dose (53, 27, and 13 times of the equivalent clinical dose), no toxicity within 14 days, normal activities such as respiration and feeding, and their body weights increased by 6.97% and 6.67% respectively. Rabbit intact skin and damaged skin, a single administration for 7 days, were not irritating; eleven square wine on the skin of guinea pigs without allergy. Conclusion: Eleven prescription wine has no acute toxicity and irritation to rabbits skin and has no sensitization to guinea pig skin.