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为研究放疗前基于细胞动力学的化疗有否增益,作者选无远处转移的晚期头颈部鳞癌64例于放疗前随机对47例分别在第1、14天用方案Ⅰ、Ⅱ序贯化疗:I.oh:长春新硷1.5mg/Miv→12h:氢考500mgiv+MT×75mg/Miv→15h:MTX75mg/Miv→18h:5-Fu350mg/Miv+氢考500mgiv+MTX75mg/Miv→26h:叶酸15mg qlh X46him 或Po(其中第12-18h 再静滴争光霉素60mg)。Ⅱ、oh:羟基尿3g/M→6h:6-MP150mg/MPo→12h:CTX500mg/Miv。约在第28天开始
To study whether chemotherapy based on cell kinetics had gain before radiotherapy, the authors selected 64 patients with advanced head and neck squamous cell carcinoma without distant metastasis before radiotherapy and randomized 47 patients on the first and 14th days respectively. Chemotherapy: I.oh: Changchun Xinjing 1.5mg/Miv→12h: Hydrogenation 500mgiv+MT×75mg/Miv→15h: MTX 75mg/Miv→18h: 5-Fu350mg/Miv+ Hydrogen 500mgiv+MTX 75mg/Miv→26h: Folic acid 15mg qlh X46him or Po (in which the first 12-18h reinstillation of bleomycin 60mg). II, oh: Hydroxyuria 3 g/M→6 h: 6-MP 150 mg/MPo→12 h: CTX 500 mg/Miv. About the 28th day