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建立了2-甲基苯并咪唑类异黄酮衍生物的合成方法.其中脱氧安息香3以间苯二酚和取代苯乙酸为原料用微波促进法合成,化合物3再与醋酐反应得到化合物4,其在酸性条件下转化成化合物5.化合物5分别与1,2-二溴乙烷和1,3-二溴丙烷在丙酮溶液中回流得到化合物6和7,最后目标化合物分别由化合物6和化合物7与2-甲基苯并咪唑在无水碳酸钾催化下丙酮中回流得到.利用IR,1HNMR,13CNMR,元素分析等对目标化合物的结构进行了表征.在目标化合物的合成中,不仅对C—O键和C—N键建立的反应条件进行了优化,而且将微波促进法成功地应用到了目标化合物的合成中,极大地缩短了反应时间.目标化合物抗氧化活性研究表明,12种目标化合物均具有较强的清除羟基自由基的能力.
A method for the synthesis of 2-methylbenzimidazole isoflavone derivatives was established, in which deoxybenzoin 3 was synthesized by the microwave method using resorcinol and substituted phenylacetic acid as starting materials, and then compound 3 was reacted with acetic anhydride to give compound 4, Under acidic conditions, it was converted to compound 5. Compound 5 was refluxed with 1,2-dibromoethane and 1,3-dibromopropane in acetone solution to give compounds 6 and 7, respectively, and finally the target compound was synthesized from compound 6 and compound 7 and 2-methylbenzimidazole were refluxed in acetone catalyzed by anhydrous potassium carbonate.The structures of the target compounds were characterized by IR, 1HNMR, 13CNMR and elemental analysis.In the synthesis of target compounds, not only C -O bond and C-N bond were optimized, and the microwave-assisted method was successfully applied to the synthesis of the target compound, which greatly shortened the reaction time.Study on the antioxidant activity of the target compounds showed that 12 kinds of target compounds Have a strong ability to scavenge hydroxyl radicals.