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本文研究心得安、异搏定引起原发性高血压大鼠(SHR)降压过程中血浆心钠素(A)和精氨酸加压素(AVP)含量,以及心房、肾、胰腺、脾、脑组织中ANF含量。动物随机分为3组:对照组、心得安组和异搏定组。结果血浆ANF件别为26.89±2.95,20.80±6.77(P<0.01),13.76±4.69(P<0.01)ng/ml,实验组均显著降低,血浆AVP对照组为13.65±0.92,心得安组为2364±15.29(P<0.01)显著升高,异搏定组为12.58±1.85(P<0.05)pg/ml显著降低。实验组脑干ANF明显降低;左右心房、脑半球ANF明显升高。提示:SHR血浆及所测组织中均有ANF或ANF样免疫活性物质存在,且在降压过程中,ANF合成与释放均有明显改变并与AVP相互制约共同发挥调节作用。
This study was propranolol and verapamil induced plasma atrial natriuretic peptide (ANP) and arginine vasopressin (AVP) levels during the antihypertensive process in SHR rats, as well as atrial, kidney, pancreas, spleen , ANF content in brain tissue. Animals were randomly divided into 3 groups: control group, propranolol and verapamil group. Results The plasma levels of ANF were 26.89 ± 2.95,20.80 ± 6.77 (P <0.01) and 13.76 ± 4.69 (P <0.01) ng / ml in the experimental group, and the plasma AVP control group was 13.65 ± 0.92 2364 ± 15.29 (P <0.01), and the level of pg / ml was significantly lower in the treatment group (12.58 ± 1.85, P <0.05). ANF in experimental group decreased significantly; ANF in left and right atrium and cerebral hemisphere increased significantly. It is suggested that both ANF or ANF-like immunoreactive substances are present in the plasma of SHR and the tissues tested, and the synthesis and release of ANF are significantly changed during the process of antihypertensive treatment and play a regulatory role with the restriction of AVP.