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比较性观察阿曲库铵和维库溴铵量-效关系和恢复时相特征。选择60例ASAI级，年龄17～50岁，施择期整形外科手术的中国患者，分层随机平均分成阿曲库铰组和维库溴铵组。用60％NO2-O2-硫喷妥钠-芬太尼维持麻醉。用加速度仪监测神经肌肉功能，采用TOF刺激方式，以T1抑制的百分比为研究指标。用累计给药方法建立阿曲库铵和维库溴铵的量-效关系曲线。根据用最小二乘法建立的量-效关系曲线，阿曲库铵的神经肌肉阻滞作用强度仅为维库溴铵的17％。两药的ED50、ED90和ED95均有明显差别。应用等效剂量（1.5×ED95）后，两药的高峰时间、临床肌松时间、恢复时间和体内作用时间均无明显差别。结论：阿曲库铵是一弱效能的肌松药，而维库溴接为一强效能肌松药。阿曲库按和维库溴铵的作用强度比率为1／6。应用等效剂量后，两药的恢复时相无明显差别。
A comparative study of the relationship between dose-effect and recovery of atracurium and vecuronium. Sixty Chinese patients with ASAI grade, aged 17 to 50 years undergoing orthopedic surgery were randomly divided into atracurium group and vecuronium group randomly. Anesthesia was maintained with 60% NO2-O2-thiopental-fentanyl. Neuromuscular function was monitored by accelerometer and TOF stimulation was used. The percentage of T1 inhibition was taken as the research index. The dose-response curves of atracurium and vecuronium were established by cumulative administration. According to the dose-response curve established by the least-squares method, atracurium exerts a neuromuscular blockade of only 17% of vecuronium. Two drugs ED50, ED90 and ED95 are significantly different. After application of equivalent dose (1.5 × ED95), the peak time of two drugs, clinical muscle relaxation time, recovery time and the role of body time were not significantly different. CONCLUSION: Atracurium is a weak potency of muscle relaxant, whereas vecuronium is a potent muscle relaxant. Atracurium and vecuronium intensity ratio of 1/6. After applying the equivalent dose, there was no significant difference between the two drugs in the recovery phase.