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已知右心室对压力超负荷的适应是肺动脉高压(pulmonary arterial hypertension,PAH)患者预后的主要影响因素。为了评估右心室适应和负荷之间的关系,然后比较PAH中不同负荷适应性指数的预后价值,Amsallem及其同事纳入推导队列(n=85)和验证队列(n=200),使用3种方法评估负荷适应性:①脑室动脉耦合的替代物(例如右心室面积变化/收缩末期面积);②功能和负荷的简比(例如三尖瓣环收缩期位移/
The adaptation of right ventricle to pressure overload is known to be a major prognostic factor in patients with pulmonary arterial hypertension (PAH). To assess the relationship between right ventricular adaptation and load, and then to compare the prognostic value of different load-fit indices in PAH, Amsallem and colleagues included a derivation cohort (n = 85) and a validation cohort (n = 200) Assessment of load adaptability: â ’¢ alternative ventricular artery coupling (eg, right ventricular area change / end-systolic area); â’ simple function and load (such as tricuspid annulus systolic displacement /