论文部分内容阅读
药理试验表明丹参酮IIA及隐丹参酮等有耐缺氧作用。丹参酮IIA等的耐缺氧作用,可能与其邻醌结构有关。我们合成了一些改变醌式结构的丹参酮类似物,经试验,它们的耐缺氧作用减弱。丹参酮IIA由于磺酸基的引入而成水溶性化合物,临床试验对冠心病有效。但存在一些缺点,为了寻找更好的水溶性的丹参酮类化合物,合成了若干丹参酮Ⅰ和IIA的Mannich碱,药理试验表明有较好的抑菌作用。有关心血管方面的药理将另文报道。
Pharmacological tests showed that tanshinone IIA and cryptotanshinone are hypoxic-tolerant. The hypoxia-resistance of tanshinone IIA, etc., may be related to its adjacent oxime structure. We synthesized some tanshinone analogs that changed the quinone structure. After testing, their hypoxic tolerance weakened. Tanshinone IIA is a water-soluble compound due to the introduction of sulfonic acid groups, and clinical trials are effective for coronary heart disease. However, there are some disadvantages. In order to find better water-soluble tanshinones, a number of Mannich bases of tanshinone I and IIA have been synthesized, and pharmacological tests have shown that they have better antibacterial activity. Pharmacology related to cardiovascular disease will be reported separately.