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目的:探讨醋酸地塞米松对替硝唑大鼠体内药动学的影响。方法:大鼠随机分为两组,每组5只,一组灌胃给予替硝唑,另一组灌胃给予醋酸地塞米松,连续5 d,于第6天合并给药替硝唑与醋酸地塞米松,分别测定两组大鼠血浆中替硝唑的浓度,用DAS软件程拟合药动学参数。结果:单独给予替硝唑组和联合给药组的替硝唑的主要药动学参数:C_(max)分别为(27.08±2.98)和(23.69±3.45)mg·L~(-1),t_(1/2):(2.16±0.76)h和(1.95±0.31)h,AUC_(0-24h):(138.04±5.84)和(1 19.90±11.46)mg·h·L~(-1)。两组间AUC及CL/F的差异有统计学意义(P<0.05)。结论:醋酸地塞米松对替硝唑大鼠体内药动学过程影响较小。
Objective: To investigate the effect of dexamethasone acetate on the pharmacokinetics of tinidazole in rats. Methods: The rats were randomly divided into two groups with 5 rats in each group. One group received intragastric administration of tinidazole and the other intragastrically administered dexamethasone acetate for 5 days. On the 6th day, tinidazole Dexamethasone acetate were used to determine the concentration of tinidazole in plasma of two groups respectively. The pharmacokinetic parameters were fitted by DAS software. RESULTS: The main pharmacokinetic parameters of tinidazole in the tinidazole group and the combination group were Cmax 27.08 ± 2.98 and 23.69 ± 3.45 mg · L -1, respectively, t 1/2: 2.16 ± 0.76 h and 1.95 ± 0.31 h, AUC 0-24 h: (138.04 ± 5.84) and (19.90 ± 11.46) mg · h · L -1, respectively. . The difference of AUC and CL / F between the two groups was statistically significant (P <0.05). Conclusion: Dexamethasone acetate has little effect on the pharmacokinetics of tinidazole in rats.