英国利兹大学的Dianne Berry教授及其同事在2002年3月的《柳叶刀》上发表文章称,当患者通过一些含糊的形容词如常见、少见等来了解药物不良反应的有关信息时,往往会过高估计药物的不良反应。 Berry教授及其同事指出,1999年1月起生效的欧共体指导手册上将药物不良反应的发生率分成5个级别,发生率小于0.01％的被称之为“非常少见”, Professor Dianne Berry of the University of Leeds, UK, and colleagues published an article in the March 2002 issue of The Lancet, when patients often learn about adverse drug reactions using vague adjectives such as common and infrequent information Overestimate adverse drug reactions. Professor Berry and colleagues point out that the EU guidance handbook, which took effect in January 1999, divides the incidence of adverse drug reactions into five levels and the incidence of less than 0.01% is called “very rare”