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目的:科学评价术前舌下含服米索前列醇用于无痛人流的临床效果。方法:选择于2007年1月至2008年12月在镇江市第二人民医院施行无痛人流术的孕妇300例,分为3组,A组(100例),术前60min舌下含服米索前列醇,术中丙泊酚配伍芬太尼静脉注射;B组(100例),丙泊酚配伍芬太尼静脉注射;C组(100例),异丙酚静脉注射。比较3种镇痛方式对孕妇收缩压(SBP)、舒张压(DBP)、心率(HR)和氧饱和度(SpO2)变化,镇痛效果、宫颈扩张程度、术中出血量、术后恶心、呕吐等不良反应、异丙酚的总用量、手术时间和苏醒时间。结果:3种镇痛方式中,A组孕妇扩宫时SBP、DBP、HR、SpO2变化,镇痛效果,宫颈扩张程度,术中出血量,术后恶心、呕吐等不良反应,异丙酚的总用量,手术时间优于B组、C组。C组苏醒时间短于A组、B组。结论:术前60min舌下含服米索前列醇用于无痛人流扩宫满意度高、手术时间短、异丙酚的用量少、安全、有效、可靠。
Objective: To evaluate the clinical effect of preoperative sublingual misoprostol for painless abortion. Methods: From January 2007 to December 2008 in Zhenjiang Second People’s Hospital of painless abortion in pregnant women 300 cases, divided into three groups, A group (100 cases), 60min preoperative sublingual dose of rice Supramostat, intraoperative propofol with fentanyl intravenous injection; B group (100 cases), propofol with fentanyl intravenous injection; C group (100 cases), propofol intravenous injection. The changes of SBP, DBP, HR and SpO2, analgesic effect, cervical dilatation, intraoperative blood loss, postoperative nausea, Vomiting and other adverse reactions, the total amount of propofol, operation time and wake up time. Results: Among the three kinds of analgesia, the adverse reactions such as SBP, DBP, HR, SpO2 changes, analgesic effect, cervical dilatation, intraoperative blood loss, postoperative nausea and vomiting, The total amount of operation time is better than the B group, C group. C group wake time is shorter than A group, B group. CONCLUSION: The sublingual administration of misoprostol at 60 min before operation is satisfactory for painless dilation and has short operation time and less dosage of propofol. It is safe, effective and reliable.