论文部分内容阅读
摘要目的评估猪模型中经皮胰腺灌注(PIPP)法的可行性。材料与方法实验均获得公共动物实验伦理委员会批准。15头猪被分为5组,分别实行PIPP。进行血管成像和注入对比染色剂以确保PIPP系统的开放性(第一组)。体外循环中含有顺铂的血液以3种不同的注射流率进入胰腺循环中(40、60及80 m L/min),用来得到合适的注射流率以确保安全性及药理有效性(第2、3、4组中)。第5组使用最佳注射流率进行实验,分别评估按时间顺序得到的实验数据以及组
Abstract Objective To evaluate the feasibility of percutaneous pancreatic perfusion (PIPP) in swine model. Materials and methods experiments have been approved by the Public Animal Experimental Ethics Committee. 15 pigs were divided into 5 groups and PIPP was implemented. Vascular imaging and infusion of contrast dyes were performed to ensure the openness of the PIPP system (group 1). Cisplatin-containing blood in the extracorporeal circulation enters the pancreatic circulation at 3 different injection rates (40, 60, and 80 mL/min) to obtain an appropriate injection flow rate to ensure safety and pharmacological efficacy. 2, 3, 4 groups). Group 5 uses the best injection rate for experiments to evaluate the experimental data and groups obtained in chronological order