论文部分内容阅读
糖尿病肾病是糖尿病常见且严重的微血管并发症之一。肾脏改变除与局部血流动力学改变有关,还可能与激活肾素——紧张素——醛固酮系统(RAS)有关。ACEI类药物通过降低局部的RAS活性及阻断Ang Ⅱ对肾小管间质纤维细胞的促分化作用,并减少蛋白尿,延缓肾功能恶化。本人对41例2型糖尿病肾病患者进行为期12个月的随机、双盲安慰剂对照研究,以观察ACEI对其肾脏的影响,现报告如下:
Diabetic nephropathy is one of the common and serious microvascular complications of diabetes. In addition to renal changes associated with local hemodynamic changes may also be related to the activation of renin-angiotensin-aldosterone system (RAS). ACEI drugs can reduce the local RAS activity and block the differentiation of renal interstitial fibroblasts induced by Ang Ⅱ and reduce proteinuria and delay the deterioration of renal function. I am 41 cases of type 2 diabetic nephropathy patients for a 12-month randomized, double-blind placebo-controlled study to observe the impact of ACEI on their kidneys, are as follows: