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目的:评估血浆甘氨酸水平与急性心肌梗死(acute myocardial infarction,AMI)的关系。方法:收集2008年至2010年2 948例稳定型心绞痛患者,检测其血清低密度脂蛋白胆固醇(LDL-C)及相应的载脂蛋白B(Apo B)和高密度脂蛋白胆固醇(HDL-C)及相应的载脂蛋白AI(Apo AI)水平;用高效液相色谱-串联质谱法测定血浆甘氨酸水平;记录每个患者相关危险因素(性别、年龄、吸烟、肥胖、高血压、糖尿病)的情况。用多因素Cox比例风险回归模型分析4组血浆甘氨酸水平对发生急性心肌梗死事件的影响。结果:随访5年,共389例发生AMI。血浆甘氨酸水平较高的患者具有较低的肥胖率、高血压率及患糖尿病率(P<0.05)。相关危险多因素分析显示,血浆甘氨酸水平与AMI的发生呈负相关(hazard ratio per SD:0.89,95%CI为0.82~0.98,P=0.017)。在载脂蛋白B、LDL-C和Apo AI水平高于中值的患者中,血浆甘氨酸水平与AMI的发生呈负相关关系更明显。结论:血浆甘氨酸水平作为一个独立的因素与稳定型心绞痛患者急性心肌梗死的发生率呈负相关。
Objective: To evaluate the relationship between plasma glycine level and acute myocardial infarction (AMI). Methods: A total of 2948 patients with stable angina pectoris from 2008 to 2010 were enrolled in this study. Serum LDL-C, Apo B and HDL-C ) And corresponding apolipoprotein AI (Apo AI). Plasma glycine levels were determined by high performance liquid chromatography-tandem mass spectrometry. The risk factors (gender, age, smoking, obesity, hypertension, diabetes) in each patient were recorded Happening. The effects of four groups of plasma glycine levels on the occurrence of acute myocardial infarction were analyzed by multivariate Cox proportional hazards regression model. Results: During the follow-up of 5 years, a total of 389 patients had AMI. Patients with high plasma glycine levels had lower rates of obesity, hypertension, and diabetes (P <0.05). Correlated risk Multivariate analysis showed that plasma glycine levels were negatively correlated with AMI (hazard ratio per SD: 0.89, 95% CI 0.82-0.98, P = 0.017). In patients with apolipoprotein B, LDL-C and Apo AI levels above the median, there was a negative correlation between plasma glycine levels and AMI. CONCLUSIONS: Plasma glycine levels as a independent factor have a negative correlation with the incidence of acute myocardial infarction in patients with stable angina.