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目的观察不同浓度的阿霉素用于三叉神经痛毁损治疗的临床效果和副作用。方法选择三叉神经痛患者76例,随机分为3组:0.33%阿霉素组、0.5%阿霉素组和1%阿霉素组。根据疼痛的部位不同选择相应的神经干或神经末梢注射不同浓度的阿霉素,观察记录3组患者神经毁损后2周、6个月、2年的疼痛强度和缓解程度以及毁损的副作用。结果0.33%组阿霉素2周、6个月、2年的疼痛缓解度远低于另外两组(P<0.05)。0.5%和1%阿霉素组的2周、6个月的临床疗效无统计学差异(P>0.05),但2年疗效1%的阿霉素明显优于0.5%的阿霉素组(P<0.05)。结论0.5%和1%浓度的阿霉素对三叉神经痛治疗效果较好,1%浓度的阿霉素远期疗效好于0.5%的阿霉素,但副作用较明显。
Objective To observe the clinical effects and side effects of different concentrations of doxorubicin for the treatment of trigeminal neuralgia. Methods Trigeminal neuralgia patients were randomly divided into three groups: 0.33% doxorubicin group, 0.5% doxorubicin group and 1% doxorubicin group. According to the different parts of the pain, the corresponding nerve stem or nerve endings were injected with different concentrations of doxorubicin. The pain intensity and degree of remission and the side effects of the damage were recorded at 2 weeks, 6 months and 2 years after the nerve damage in 3 groups. Results 0.33% of doxorubicin 2 weeks, 6 months, 2 years pain relief was much lower than the other two groups (P <0.05). There was no significant difference in clinical efficacy between 0.5% and 1% doxorubicin for 2 weeks and 6 months (P> 0.05), but 1% doxorubicin with 2 years efficacy was significantly better than 0.5% doxorubicin P <0.05). Conclusion 0.5% and 1% doxorubicin has a good effect on the treatment of trigeminal neuralgia. The long-term efficacy of 1% doxorubicin is better than that of doxorubicin at 0.5%, but the side effects are obvious.