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一、前言近年来关于肾上腺皮质激素醛固酮的知识日益丰富,许多实验室和临床的资料均表明,醛固酮在多种水肿及腹水的发病学上具有重要作用。临床土曾发现在充血性心力衰竭、肝硬化腹水和肾病综合症病人的尿中,醛固酮大量增加。Luetscher等从一类脂性肾病病儿13天的尿中共分离出1000微克的结晶状醛固酮,而在正常人尿中则仅合微量。由于肺动脉狭窄而产生的实验性充血性心力衰竭的狗,肾上腺静脉血液和尿中的醛固酮量均有增加。Stahl实验结扎狗的门静脉使门脉压显著增高,此时并不能形
I. Introduction In recent years, the knowledge of adrenal corticosteroid aldosterone has been increasingly enriched. Many laboratory and clinical data indicate that aldosterone plays an important role in the pathogenesis of various edema and ascites. Clinical soil has been found in patients with congestive heart failure, cirrhosis and nephrotic syndrome, urinary aldosterone increased significantly. Luetscher et al. Isolated 1000 micrograms of crystalline aldosterone from the 13-day urine of a group of patients with nephrotic nephropathy, whereas only slightly in normal human urine. The amount of aldosterone in both venous blood of the adrenal glands and urine of experimental congestive heart failure due to pulmonary stenosis increased. Stahl experiment ligation of the dog’s portal vein so that significantly increased portal pressure, this time does not form