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目的:观察宫颈癌放射治疗的临床疗效。方法:随机选取2007年1月~2009年12月在我院接受放射治疗的54例宫颈癌患者,所有患者均采用高剂量率后装治疗,对54例接受放射治疗患者进行随访,并评估5a存活率。结果 :所有患者均完成相应治疗,对54例接受放射治疗患者的5a存活率进行评估。其中,Ⅰ期5a存活率为100%(10/10),Ⅱ期5a存活率为87.10%(27/31),Ⅲ期5a存活率为57.14%(8/14),全组5a存活率合计为83.33%(45/54)。局部复发8(14.81%)例,局部复发并远处转移2(3.70%)例,局部未控3(5.56%)例。对不良反应发生情况进行分析,其中1、2级膀胱炎22(40.74%)例,3、4级膀胱炎5(9.26%)例,1、2级直肠炎31(57.41%)例,3、4级直肠炎7(12.96%)例,1、2级皮肤反应35(64.81%)例,3、4级皮肤反应9(16.67%)例,1、2级血液毒性6(11.11%)例,3、4级血液毒性1(1.86%)例。结论 :高剂量率放射治疗宫颈癌临床疗效较好,5a存活率高,值得临床推广应用。
Objective: To observe the clinical efficacy of radiotherapy for cervical cancer. METHODS: Fifty-four patients with cervical cancer undergoing radiotherapy in our hospital from January 2007 to December 2009 were randomly selected. All patients were treated with high-dose rate after-treatment and 54 patients undergoing radiotherapy were followed up and evaluated for 5a Survival rate. Results: All patients completed the appropriate treatment and 54 patients who underwent radiotherapy were evaluated for 5-year survival. Among them, the survival rate of stage 5a was 100% (10/10), the survival rate of stage 5a was 87.10% (27/31), the survival rate of stage 5a was 57.14% (8/14) 83.33% (45/54). Local recurrence 8 (14.81%) cases, local recurrence and distant metastasis 2 (3.70%) cases, the local uncontrolled 3 (5.56%) cases. The incidences of adverse reactions were analyzed. Among them, 22 (40.74%) had grade 1 cystitis, 5 (9.26%) had grade 3 cystitis 4, 31 (57.41%) had 1 grade 3 proctitis, 4 cases of proctitis 7 (12.96%), 1,2 cases of skin reaction 35 (64.81%) cases, 3,4 cases of skin reaction 9 (16.67%) cases, 1,2 hematological toxicity 6 (11.11%) cases, Grade 3 Hemotoxicity 1 (1.86%) cases. Conclusion: The high dose rate radiotherapy for cervical cancer has better curative effect and 5a survival rate, which is worthy of clinical application.