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目的观察自制复方连芩双层缓释药膜与金莲清热泡腾片联合常规方法治疗小儿手足口病的临床效果。方法将200例手足口病患儿随机分为A、B组各100例。试验组患儿采用自制复方连芩双层缓释药膜与金莲清热泡腾片联合常规方法进行治疗,对照组患儿采用金莲清热泡腾片联合常规方法进行治疗。对比2组临床疗效、中医症候改善情况和退热时间、溃疡愈合时间、斑疹消退时间及治疗时间。结果试验组总有效率为93.0%高于对照组的74.0%,差异具有统计学意义(P<0.01)。试验组患儿中医症候改善情况明显高于对照组,差异具有统计学意义(P<0.05)。试验组患儿退热时间、溃疡愈合时间、斑疹消退时间及治疗时间均短于对照组,差异具有统计学意义(P<0.05)。2组患儿在治疗过程中均未出现明显不良反应。结论采用自制复方连芩双层缓释药膜与金莲清热泡腾片联合常规方法对小儿手足口病进行治疗,临床疗效较好、中医症候改善明显,能够使患儿临床症状消退时间明显缩短,无明显不良反应,具有较高临床应用价值。
Objective To observe the clinical effects of self-made double-coated sustained-release Lianqin skullcap and Chinese medicinal lotus leaf-heat tablets in the treatment of hand-foot-mouth disease in children. Methods 200 cases of HFMD were randomly divided into A and B groups of 100 cases. Children in the experimental group were treated with self-made double-coated sustained-release Ligustrazine and radiant heat-effervescent tablet, and the control group was treated with the Chinese radiant heat-effervescent tablet combined with the conventional method. The clinical curative effect, TCM symptom improvement, antipyretic time, ulcer healing time, spotted elimination time and treatment time were compared between the two groups. Results The total effective rate of the experimental group was 93.0% higher than that of the control group (74.0%), the difference was statistically significant (P <0.01). The improvement of TCM symptoms in children in experimental group was significantly higher than that in control group (P <0.05). The experimental group of children with antipyretic time, ulcer healing time, spot elimination and treatment time were shorter than the control group, the difference was statistically significant (P <0.05). Two groups of children in the course of treatment did not appear obvious adverse reactions. Conclusion The self-made double-coated sustained-release Ligustrazine Scutellaria and Clematis tablets combined with the conventional method of treatment of children with hand-foot-mouth disease, clinical efficacy is better, significantly improved Chinese medicine symptoms, can make children with clinical symptoms subsided significantly shorter, No obvious adverse reactions, with high clinical value.