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[Objective] To investigate the chemical compositions from the cortex of Broussonetia papyrifera.[Method] The cortices of Broussonetia papyrifera were extracted with 95% ethanol.The EtOH extract was dispersed in H2O and extracted with petroleum,EtOAc and BuOH successively.The EtOAc fraction was isolated and purified by column chromatography on silica gel and Sephadex.The compounds were identified on the basis of spectral analysis (including MS,1H-NMR,1C-NMR).[Result] Nine compounds were isolated from the cortex of Broussonetia papyrifera,and its structure was characterized as kazinol B(1),7,4’-dihydroxy-3’-prenylflavan(2),7,3’-dihydroxy-4’-methoxyflavan(3),kazinol A (4),3’-(3-methylbut-2-enyl)-3’,4’,7-trihydroxyflavane(5),Broussochalcone A (6),oleanolic acid (7),2’,3β-dihydroxy-12-oleanen-28-oic acid (80),daucosterol (9).[Conclusion] 3,7,8 were obtained from the cortex of Broussonetia papyrifera for the first time.The antibacterial test showed that compound 1,2,5,7 had better inhibition on S.m ATCC25175,A.n ATCC12104,P.g ATCC33277 and F.n ATCC10953.
[Objective] To investigate the chemical compositions from the cortex of Broussonetia papyrifera. [Method] The cortices of Broussonetia papyrifera were extracted with 95% ethanol. The EtOH extract was dispersed in H2O and extracted with petroleum, EtOAc and BuOH successively. EtOAc fraction was isolated and purified by column chromatography on silica gel and Sephadex. The compounds were identified on the basis of spectral analysis (including MS, 1H-NMR, 1C-NMR). [Result] Nine compounds were isolated from the cortex of Broussonetia papyrifera, and its structure was characterized as kazinol B (1), 7,4’-dihydroxy-3’-prenylflavan (2), 7,3’-dihydroxy- - 3-methylbut-2-enyl-3 ’, 4’, 7-trihydroxyflavane (5), Broussochalcone A (6), oleanolic acid (7), 2 ’, 3β-dihydroxy-12-oleanen-28- acid (80), daucosterol (9). [Conclusion] 3,7,8 were obtained from the cortex of Broussonetia papyrifera for the first time. The antibacterial test showed that compound 1,2,5,7 had better inhibitio n on S.m ATCC 25175, A.n ATCC12104, P.g ATCC33277 and F.n ATCC10953.