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通过控制加热温度,将甲氧氯普胺Ⅰ剖转变为Ⅱ型。对Ⅰ型和Ⅱ型晶体进行了差热分析、红外光谱、X-射线粉末衍射测定和偏光显微镜观察,测定了两种晶型在水中和在0.1 mol/L盐酸溶液中的溶解度,并计算了两种晶型在水中溶解时的热力学参数。结果表明在不同的温度下可引起两种晶型的互变,有机溶剂重结晶可使甲氧氯普胺Ⅱ型转变为Ⅰ型,研磨不能引起晶型的转变。在实验温度下,甲氧氯普胺Ⅱ型在水中和在盐酸溶液中的溶解度均比Ⅰ型的溶解度稍大,甲氧氯普胺Ⅰ型和Ⅱ型在水中的溶解热分别为11.50和9.99 kJ/mol。
By controlling the heating temperature, metoclopramide Ⅰ split into Ⅱ type. Differential thermal analysis, IR, X-ray powder diffraction and polarized light microscopy were performed on type I and type II crystals. The solubility of the two crystal forms in water and 0.1 mol / L hydrochloric acid solution was measured and calculated Thermodynamic parameters of two crystal forms dissolved in water. The results show that at different temperatures can cause the interconversion of two crystalline forms, recrystallization of organic solvents can make metoclopramide Ⅱ into Ⅰ, grinding can not cause the transformation of the crystal form. At experimental temperature, the solubility of metoclopramide type Ⅱ in water and in hydrochloric acid solution was slightly greater than that of type Ⅰ, and metoclopramide type Ⅰ and Ⅱ in water were 11.50 and 9.99, respectively kJ / mol.