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目的探讨应用国产氯吡格雷(泰嘉)治疗不稳定性心绞痛的临床疗效。方法选择2009年10月至2010年5月我院收治的120例不稳定性心绞痛患者,并分成对照组和观察组两组,每组各60例。对两组患者均实施常规治疗,对照组患者在常规治疗的基础上加用进口氯吡格雷,75mg/次,1次/日。观察组患者在常规治疗的基础上加用国产氯吡格雷治疗,75mg/次,1次/日。两组均以连续治疗四周为一个疗程。比较两组不良反应总发生率,治疗总有效率及心电图疗效。结果比较观察组和对照组不良反应总发生率和心电图治疗总有效率,均无显著性差异,因而差异无统计学意义。观察组和对照组治疗总有效率分别为91.6%、90%,比较两组治疗效果没有显著性差异,因而不具有统计学意义(P>0.05)。结论对于不稳定性心绞痛,应用国产氯吡格雷治疗和进口氯吡格雷具有相同的临床治疗效果。同时操作也简单安全性高,且前者价格更为优惠。临床上值得进一步推广应用。
Objective To investigate the clinical efficacy of domestic clopidogrel in the treatment of unstable angina pectoris. Methods A total of 120 patients with unstable angina pectoris admitted to our hospital from October 2009 to May 2010 were divided into control group and observation group, 60 cases in each group. The two groups of patients were given conventional treatment, the control group of patients on the basis of conventional treatment plus imported clopidogrel, 75mg / time, 1 / day. Patients in observation group were treated with domestic clopidogrel on the basis of routine treatment, 75mg / time, once / day. Two groups were treated with continuous treatment for a course of four weeks. The total adverse reaction rate, the total effective rate and the electrocardiogram curative effect were compared between the two groups. Results There was no significant difference between the total incidence of adverse reactions and the total effective rate of ECG in observation group and control group, so the difference was not statistically significant. The total effective rates of the observation group and the control group were 91.6% and 90%, respectively. There was no significant difference between the two groups in the treatment effect (P> 0.05). Conclusion For unstable angina, the application of domestic clopidogrel and imported clopidogrel have the same clinical effect. At the same time operation is also simple and safe, and the former price is more favorable. Clinically worth further promotion and application.