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目的探讨米氮平联合常规抗心衰药物治疗慢性心力衰竭伴抑郁患者的疗效。方法选取2014年1月至2015年4月我院收治的慢性心力衰竭合并抑郁的患者120例,随机分成试验组组及对照组,对照组患者采用慢性心力衰竭常规药物治疗,试验组患者采用慢性心力衰竭常规药物治疗联合米氮平15~30mg/d治疗。对比两组患者治疗前后的汉密尔顿抑郁量表评(HAMD)分及心功能。结果两组患者治疗前HAMD评分及新功能组间比较,差异无统计学意义(P>0.05)。与治疗前相比,两组患者治疗后30d、90d、180d、300d HAMD评分均降低(P<0.05);与对照组相比,试验组治疗后30d、90d、180d、300d HAMD评分更低、评分差率更高,(P<0.05)。与治疗前相比,两组患者治疗后左室射血分数及左室短轴缩短率均升高,6min步行试验距离延长,心率降低(P<0.05);与对照组相比,实验组上述心功能指标更优(P<0.05)。结论米氮平联合常规抗心衰药物治疗慢性心力衰竭伴抑郁患者的疗效更佳,值得在临床中推广和应用。
Objective To investigate the curative effect of mirtazapine combined with conventional anti-heart failure drugs in patients with chronic heart failure and depression. Methods 120 patients with chronic heart failure and depression who were admitted to our hospital from January 2014 to April 2015 were randomly divided into experimental group and control group. Patients in the control group were treated with conventional drugs of chronic heart failure. The patients in the experimental group were treated with chronic Heart failure conventional drug treatment combined with mirtazapine 15 ~ 30mg / d treatment. The Hamilton Depression Rating Scale (HAMD) score and cardiac function before and after treatment were compared between the two groups. Results There was no significant difference between the two groups in HAMD score and new functional group before treatment (P> 0.05). Compared with the control group, the HAMD scores of the two groups were significantly decreased at 30d, 90d, 180d and 300d after treatment (P <0.05). Compared with the control group, the HAMD scores of the two groups were lower at 30d, 90d, 180d and 300d after treatment Scoring rate higher (P <0.05). Compared with those before treatment, left ventricular ejection fraction and shortening rate of left ventricular shortening were increased in both groups after treatment, distance of 6min walking test was prolonged and heart rate was decreased (P <0.05). Compared with the control group, Heart function better (P <0.05). Conclusion Mirtazapine combined with conventional anti-heart failure drugs in the treatment of patients with chronic heart failure and depression has a better curative effect and is worthy of promotion and application in clinic.