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肿瘤免疫基因治疗是肿瘤生物治疗研究的热点之一,如用各种肿瘤疫苗包括肿瘤细胞疫苗活体重组疫苗、肽疫苗、树突状细胞疫苗以及DNA疫苗等,用来诱导机体抗肿瘤之反应.然而研制这些疫苗目前仍存在着一些问题,如大部分肿瘤特异性抗原仍不清楚,机体对自身抗原免疫耐受,缺乏有效的抗原递呈等.因此有必要探索肿瘤免疫或基因治疗的新途径.在正常情况下,机体对自身抗原不产生免疫应答,即自身耐受性,但当机体内隐蔽抗原释放、生物、物理化学因素使自身抗原改变等可导致自身免疫形成,同时通过多种途径作用于靶抗原所在组织及细胞,造成相应器官的病理性损伤和功能障碍.
Tumor immune gene therapy is one of the hot topics in the research of tumor biological therapy. For example, it uses a variety of tumor vaccines including tumor cell vaccine live recombinant vaccines, peptide vaccines, dendritic cell vaccines, and DNA vaccines to induce anti-tumor responses. However, there are still some problems in the development of these vaccines, such as most tumor-specific antigens are still not clear, the body is immune to self-antigen tolerance, lack of effective antigen presentation, etc. Therefore it is necessary to explore new ways of tumor immunity or gene therapy Under normal circumstances, the body does not produce an immune response to autoantigens, that is, self-tolerance, but when the body’s hidden antigen release, biological, physical and chemical factors make autoantigen changes can lead to autoimmune formation, at the same time through a variety of ways Acts on the tissues and cells where the target antigen is located, resulting in pathological damage and dysfunction of the corresponding organ.