论文部分内容阅读
磁性药物制剂是将药物和铁磁性物质共包于或共分散于载体中应用于体内,然后利用体外磁场效应引导药物在体内移动并定位集中的靶向给药制剂。这类制剂包括:1 免疫磁性微球(immunomanetic microsphere) 制备此微球一般可分2步:①制成含磁性材料的微球;②在微球表面引入活性基因如OH,COOH,NH_2等,再通过载体表面偶联反应将抗体、酶或免疫毒素结合到载体上,
Magnetic drug formulations are drugs or ferromagnetic substances co-coated or co-dispersed in a carrier for application to the body, and then use the magnetic field effect in vitro to guide the drug to move in vivo and to locate a concentrated targeted drug delivery preparation. Such preparations include: 1 immunomagnetic microsphere (immunoma microsphere) Preparation of the microspheres generally can be divided into two steps: ① made of magnetic material containing microspheres; ② microspheres introduced active genes such as OH, COOH, NH_2, etc., Then, the antibody, enzyme or immunotoxin is bound to the carrier through the carrier surface coupling reaction,