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用膜片钳全细胞记录的方法研究了勾藤碱对大鼠和豚鼠心肌细胞上电压依赖性钾通道的影响。ＣｄＣ１２０．１ｍｍｏｌ／Ｌ存在时，勾藤碱３０μｍｏｌ／Ｌ减少大鼠心肌细胞一４０至６０ｍＶ去极化时产生的瞬时外向Ｋ＋电流（ＩＡ）３０％，并减少一４０至５０ｍＶ去极化时，豚鼠心肌细胞的延迟整流Ｋ＋电流（ＩＫ）６０％，同样剂量的勾藤碱对大鼠和豚鼠心肌细胞的内向整流Ｋ＋通道（ＩＫ１）无影响。提示勾藤碱的抗心律失常作用除了Ｃａ通道阻断外，与其ｒ通道抑制作用有关。
The whole-cell patch clamp recording was used to investigate the effects of goutriol on voltage-dependent potassium channels in rat and guinea pig cardiomyocytes. In the presence of CdCl20.1 mmol / L, Gout 30 μmol / L reduced transient outward K + current (IA) by 30% at a 40-60 mV depolarization in rat cardiomyocytes and decreased by 40-50 mV depolarization, The delayed rectifier K + current (IK) of guinea pig cardiomyocytes was 60%, and the same dose of gonadotropin had no effect on the inward rectifier K + channel (IK1) of rat and guinea pig cardiomyocytes. It is suggested that the antiarrhythmic effect of goutine is related to the inhibition of r channel except Ca channel block.