研究东莨菪素在大鼠体内的组织分布和排泄特征,SD大鼠灌胃东莨菪素(50mg/kg),分别于给药后5,15,30,60,120,240分钟取大鼠心、肝、脾、肺、肾、肌肉、脂肪、脑、睾丸、子宫、胃、小肠等组织器官测定其原形药物浓度。结果表明,东莨菪素广泛分布于各组织器官且于给药后15分钟浓度即达峰值,其中肝、肾、胃和小肠含量较高。此外,东莨菪素在胆汁、尿液、粪便的排泄研究显示,胆汁、尿液、粪便的累积排泄量分别为0.032%,3.752%和0.784%。表明东莨菪素在大鼠体内主要以代谢物的形式消除。 To investigate the tissue distribution and excretion characteristics of scopolamine in rats. Sprague-Dawley rats were orally administered with 50 mg / kg of scopolamine. Rats were sacrificed at 5, 15, 30, 60, 120 and 240 minutes after administration , Lung, kidney, muscle, fat, brain, testis, uterus, stomach, small intestine and other tissues and organs to determine the prototype drug concentration. The results showed that scopolamine was widely distributed in various tissues and organs and peaked at 15 min after administration, with a high content of liver, kidney, stomach and small intestine. In addition, the excretion of scopolamine in bile, urine and stool showed that the cumulative excretion of bile, urine and stool was 0.032%, 3.752% and 0.784%, respectively. Show that scopolamine in rats mainly in the form of metabolites eliminated.