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目的:探讨丹酚酸B联合马洛替酯对刀豆蛋白和CC14引起的肝纤维化的防治作用。方法:建立刀豆蛋白致小鼠免疫性肝损伤动物模型和CC14致大鼠肝纤维化模型,观察丹酚酸B和马洛替酯单独及联合应用后对肝功能的影响。结果:丹酚酸B联合马洛替酯可显著降低刀豆蛋白所致免疫性肝损伤小鼠血清中ALT、AST、MDA及NO含量,提高肝组织SOD活性;并可显著降低CC14致肝纤维化大鼠血清中ALT、AST活性及HA及LN含量。结论:丹酚酸B联合马洛替酯联合用药可增强对肝纤维化的防治作用。
Objective: To investigate the preventive and therapeutic effects of salvianolic acid B combined with malate on the liver fibrosis induced by Concanavalin and CC14. METHODS: The animal model of immune-induced liver injury induced by Concanavalin and the rat model of hepatic fibrosis induced by CC14 were established. The effects of salvianolic acid B and malotilate alone and in combination on liver function were observed. RESULTS: Salvianolic acid B combined with malotilate significantly reduced the serum ALT, AST, MDA and NO levels in mice with immune-induced liver injury caused by Concanavalin, increased SOD activity in liver tissue, and significantly reduced the liver fibrosis induced by CC14. The activity of ALT, AST and the contents of HA and LN in rat serum were measured. Conclusion: The combined use of salvianolic acid B combined with malotilate can enhance the prevention and treatment of liver fibrosis.