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目的:研究羟基红花黄色素A(HSYA)在血瘀和正常大鼠体内的药物动力学特征。方法:采用HPLC法测定血瘀与正常大鼠血浆中HSYA的血药浓度,应用DAS 2.0求得药动学参数。结果:血瘀大鼠和正常大鼠C_(max)分别为(8.36±1.09)和(4.61±0.19)mg·L~(-1);t_(max)分别为(1.19±0.55)和(0.75±0.00)h;AUC_(0-6)分别为(23.16±2.88)和(8.68±0.93)mg·L~(-1)·h;t_(1/2β)分别为(1.00±0.30)和(0.98±0.15)h。结论:HSYA在急性血瘀大鼠体内吸收和代谢均明显慢于正常大鼠体内,说明血瘀证可以改变药物的代谢过程。
Objective: To study the pharmacokinetics of hydroxysafflor yellow A (HSYA) in blood stasis and normal rats. Methods: Plasma concentrations of HSYA in blood plasma and normal rats were measured by HPLC. Pharmacokinetic parameters were obtained by DAS 2.0. Results: The C max of blood stasis rats and normal rats were (8.36±1.09) and (4.61±0.19) mg·L -1 , t_(max) were (1.19±0.55) and (0.75) respectively. ± 0.00) h; AUC_ (0-6) were (23.16 ± 2.88) and (8.68 ± 0.93) mg · L ~ (-1) · h; t_ (1/2β) were (1.00 ± 0.30) and ( 0.98±0.15)h. Conclusion: The absorption and metabolism of HSYA in rats with acute blood stasis are significantly slower than those in normal rats, indicating that blood stasis syndrome can change the metabolic process of the drug.