论文部分内容阅读
目的总结分析新辅助放疗加根治术治疗Ⅱ期宫颈癌患者的3年、5年生存率和新辅助放疗对手术的影响以及放疗副反应,探讨新辅助放疗在Ⅱ期宫颈癌治疗中的意义。方法选取山西医科大学第二医院2003年7月至2011年4月收治的Ⅱ期宫颈癌患者109例,其中59例行新辅助放疗(盆腔外照射+腔内后装治疗)休息2到3周后行根治性手术即广泛子宫切除+盆腔淋巴结清扫术,50例行根治性放疗。结果①新辅助放疗加根治术与根治性放疗两组患者3年、5年生存率:由于随访时间较短,还不能得出有统计学意义的结论。②新辅助放疗对手术的影响:59例患者在接受新辅助放疗后均能顺利行根治性手术,且未增加术中术后并发症。③放疗副反应:新辅助放疗组放疗副反应发生率小于根治性放疗组(P<0.05),差异有统计学意义。结论新辅助放疗加根治术可使①肿瘤明显缩小甚至消失,扩大手术适应证、提高手术治愈率。②不增加手术难度及术后并发症。③降低患者近期放疗副反应和远期并发症。④降低癌细胞的活力,减少转移的几率。⑤可取得与传统根治性放疗相近甚至更高的远期生存率。
Objective To summarize the effects of neoadjuvant radiotherapy and radical mastectomy on the 3-year and 5-year survival rates of patients with stage Ⅱ cervical cancer and the effects of neoadjuvant radiotherapy on the operation and radiotherapy side effects and to explore the significance of neoadjuvant radiotherapy in the treatment of stage Ⅱ cervical cancer. Methods A total of 109 patients with stage Ⅱ cervical cancer admitted to the Second Hospital of Shanxi Medical University from July 2003 to April 2011 were selected. Among them, 59 patients underwent neoadjuvant radiotherapy (pelvic external beam plus endovascular treatment) for 2 to 3 weeks Radical surgery that is extensive hysterectomy + pelvic lymph node dissection, 50 patients underwent radical radiotherapy. Results ① Neoadjuvant radiotherapy plus radical mastectomy and radical radiotherapy in both groups 3-year, 5-year survival rate: Due to the short follow-up period, no statistically significant conclusions can be drawn. ② The impact of neoadjuvant radiotherapy on surgery: 59 patients underwent neoadjuvant radiotherapy after radical surgery, and did not increase intraoperative and postoperative complications. Â ’¢ radiotherapy side effects: neoadjuvant radiotherapy group radiotherapy side effects were less than radical radiotherapy group (P <0.05), the difference was statistically significant. Conclusions Neoadjuvant radiotherapy plus radical mastectomy can significantly reduce or even disappear the tumor, expand the indications for surgery and improve the cure rate. ② Do not increase the difficulty of surgery and postoperative complications. ③ reduce the recent side effects of radiation and long-term complications in patients with radiotherapy. ④ reduce the vitality of cancer cells, reduce the chances of metastasis. ⑤ obtainable with conventional radical radiotherapy or even higher near long-term survival rate.